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Showing posts from September, 2017

E-cigarette use in UK almost doubled in 2 years, says Europe-wide study

The research, from scientists at Imperial College London, examined e-cigarette use -- and attitudes to the devices -- across Europe between 2012 and 2014. The paper, published in the journal  Tobacco Control , found that the proportion of people in the UK who had tried an e-cigarette had increased from 8.9 per cent to 15.5 per cent -- higher than the European average. The research also showed the proportion of people across Europe who considered the devices dangerous had also nearly doubled, from 27 per cent to 51 per cent. E-cigarettes work by delivering nicotine into the lungs in the form of a vapour. The devices contain nicotine in a solution of either propylene glycol or glycerine and water, and sometimes flavourings. When a person sucks on the device, a sensor detects the air flow and heats the liquid inside the cartridge, causing it to evaporate. Experts fiercely debate whether the devices help people give up smoking, and if they are safe -- with some studies raisi...

What can Pavlov's dogs tell us about drinking?

Indeed, Pavlovian cues that predict alcohol can lead us toward addiction. And sometimes those cues can become desirable in and of themselves, as shown in a new study published in  Frontiers in Behavioral Neuroscience  by researchers from Concordia University in Montreal. "Alcohol addiction is compounded by our ability to learn about predictive cues," says Nadia Chaudhri, the study's lead author and professor in the Department of Psychology. "Conditioned reactions to those cues can trigger behaviours that result in drinking, like turning into the SAQ or reaching for a beer." The results of the study suggest that cues that predict alcohol can become highly desirable; therefore, people may keep drinking because of the pleasure derived from our interactions with them. According to this research, drinkers wishing to make a change in their habits shouldn't just focus on the booze itself, but on all the factors that surround alcohol consumption. "M...

Party on(line): The link between social media, alcohol use

MSU researchers found that when participants in a study were exposed to ads touting beer, as opposed to those selling bottled water, they were more inclined to consider drinking alcohol . "In this study we wanted to see whether just the mere exposure to alcohol messages on social media makes any difference in terms of people's expressing intentions to consume alcohol, as well as engage in alcohol-related consumption behaviors," said Saleem Alhabash, assistant professor of advertising and public relations who headed up the study. In the study, 121 participants were exposed to ads on Facebook, one group viewing ads for a brand of beer, the other a brand of bottled water. At the end of the study, as an incentive for taking part, the participants were offered one of two gift cards -- one for a bar, the other for a coffee shop. Of those who saw the beer ad, 73 percent chose the bar card. Of those who saw the water ad, only about 55 percent chose the bar card. "W...

Exploring the rise and fall of alcohol-related mortality in Scotland: Affordability

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Alcohol-related deaths (underlying trigger) in Scotland and England & Wales (E&W) by intercourse 1991-2012 Credit score: Sources: Nationwide Data for Scotland and the Workplace for Nationwide Statistics The rise and fall of alcohol-related mortality in Scotland is partly because of modifications in affordability, in response to experiences revealed in  Public Well being. New analysis has discovered that the rise in alcohol-related mortality in the course of the 1990s and early 2000s in Scotland, and the next decline, had been more likely to be defined partially by growing then lowering alcohol affordability. The analysis was undertaken to know higher what the impartial affect of the Scottish Authorities's alcohol technique was. Different components apart from the technique and the affordability of alcohol had been additionally thought-about together with migration, historic social, financial and political change, the alcohol market, soc...

How the brain makes, and breaks, a habit

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Working with a mouse mannequin, a global staff of researchers demonstrates what occurs within the mind for habits to regulate habits. Credit score: © gustavofrazao / Fotolia Not all habits are unhealthy. Some are even crucial. It is a good factor, for instance, that we will discover our means dwelling on "autopilot" or wash our palms with out having to ponder each step. However incapacity to modify from performing habitually to performing in a deliberate means can underlie dependancy and obsessive compulsive problems. Working with a mouse mannequin, a global staff of researchers demonstrates what occurs within the mind for habits to regulate habits. The research is revealed in  Neuron  and was led by Christina Gremel, assistant professor of psychology on the College of California San Diego, who started the work as a postdoctoral researcher on the Nationwide Institute on Alcohol Abuse and Alcoholism of the Nationwide Institutes of Well bein...

Pharmacist prescribes education as key to curbing opioid abuse

Writing in the latest issue of the journal  Current Pain and Headache Reports , Kaye and his co-authors argue that such technologies are no substitute for education. "Education is the foremost strategy," Kaye said. "We must educate primary care providers, surgeons, pharmacists and other health professionals, as well as patients. That education must take place prior to the starting point of opioid therapy -- and it needs to be independent of the pharmaceutical industry." The article, titled "Current State of Opioid Therapy and Abuse," lays out a grim diagnosis and alarming prognosis for opioid misuse and abuse: Opioid misuse increased by 4,680 percent between 1996 and 2011. Opioids were involved in 28,647 deaths in 2014, triple the number in 2000, and represented 61 percent of all drug overdose deaths. More than 90 percent of patients who survive a prescription opioid overdose continue to be prescribed opioids, usually by the same prescriber. Pre...

Social media use may help identify students at risk of alcohol problems

"This work underscores the central role that social networking sites, or SNSs, play in helping students coordinate, advertise and facilitate their drinking experiences," says Lynsey Romo, an assistant professor of communication at NC State and co-lead author of a paper on the work. "The study also indicates that students who are at risk of having drinking problems can be identified through SNSs." "We started this project with a threshold question: what drives students to drink and post about alcohol on SNSs," says Charee Thompson, an assistant professor of communication studies at Ohio University and co-lead author of the study. To address that question, the researchers conducted an online survey of 364 undergraduate students at a Midwestern university. The students were all over 18, reported having consumed at least one alcoholic drink in the past month, and had an active Facebook, Twitter or Instagram account. Study participants were asked about ...

Effects of maternal smoking continue long after birth

Nicotine does this by affecting a master regulator of DNA packaging, which in turn influences activity of genes crucial to the formation and stabilization of synapses between brain cells, according to the study published online May 30 in the journal  Nature Neuroscience . "When this regulator is induced in mice, they pay attention to a stimulus they should ignore,'' said Marina Picciotto, the Charles B.G. Murphy Professor of Psychiatry, professor in the Child Study Center and the Departments of Neuroscience and Pharmacology, and senior author of the paper. An inability to focus is the hallmark of attention deficit hyperactivity disorder and other behavioral disorders, which have been linked to maternal smoking and exposure to second-hand smoke. However, scientists did not understand how early environmental exposure to smoking could create behavioral problems years later. Picciotto's lab found that mice exposed to nicotine during early development did indeed dev...

Narcotic painkillers prolong pain in rats, says study

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Brace for one more shot throughout the bow: Opioids like morphine have now been proven to paradoxically trigger a rise in persistent ache in lab rats, findings that would have far-reaching implications for people, says a brand new examine. Credit score: © jordieasy / Fotolia The darkish aspect of painkillers -- their dramatic improve in use and skill to set off abuse, dependancy and hundreds of deadly overdoses yearly in the USA is within the information nearly day-after-day. Brace for one more shot throughout the bow: Opioids like morphine have now been proven to paradoxically trigger a rise in persistent ache in lab rats, findings that would have far-reaching implications for people, says a brand new examine led by the College of Colorado Boulder. Led by CU-Boulder Assistant Analysis Professor Peter Grace and Distinguished Professor Linda Watkins, the examine confirmed that only a few days of morphine therapy brought about persistent ache that we...

Analysis exhibits that girls have better issue with smoking cessation than males. Credit score: © Serhiy Kobyakov / Fotolia     Ladies who need to stop smoking might have higher success by rigorously timing their stop date with optimum days inside their menstrual cycle, in line with a brand new examine from researchers on the Perelman College of Drugs on the College of Pennsylvania. The outcomes, revealed on-line this month in Biology of Intercourse Variations, had been additionally introduced on the annual assembly of the Group for the Research of Intercourse Variations (OSSD), held at Penn. Cigarette smoking stays the main reason behind preventable loss of life in the USA, and ladies expertise extra extreme well being penalties from cigarette smoking than males, together with a 25 % elevated threat of creating coronary coronary heart illness and persistent obstructive pulmonary illness. Analysis additionally exhibits that girls have better issue with smoking cessation than males. "Understanding how menstrual cycle section impacts neural processes, cognition and habits is a important step in creating simpler remedies and in choosing the right, most individualized therapy choices to assist every cigarette smoker stop," mentioned the examine's lead creator, Reagan Wetherill, PhD, a analysis assistant professor of Psychology. Wetherill and senior creator Teresa Franklin, PhD, a analysis affiliate professor of Neuroscience in Psychiatry, have been finding out the brains of premenopausal ladies who smoke cigarettes for a number of years in Penn's Heart for the Research of Dependancy. Their work relies on a major animal literature exhibiting that the pure intercourse hormones -- estrogen and progesterone -- which fluctuate over the course of the menstrual cycle modulate addictive habits. The animal information present that in the course of the pre-ovulatory, or follicular section of the menstrual cycle, when the progesterone-to-estrogen ratio is low, ladies usually tend to be spurred towards addictive behaviors. Alternatively, in the course of the early pre-menstrual or luteal section of the menstrual cycle, when the progesterone-to-estrogen ratio is excessive, addictive behaviors are thwarted, suggesting that progesterone may defend ladies from relapsing to smoking. Within the present examine, 38 bodily wholesome, premenopausal ladies who smoke and who weren't taking hormonal contraceptives, starting from 21 to 51 years of age, acquired a practical MRI scan to look at how areas of the mind that assist management habits are functionally linked to areas of the mind that sign reward. The researchers theorized that the pure fluctuations in ovarian hormones that happen over the course of the month-to-month menstrual cycle have an effect on how ladies make choices relating to reward -- smoking a cigarette -- and so-called "smoking cues," that are the individuals, locations and issues that they affiliate with smoking, such because the odor of a lit cigarette or happening their espresso break. These "appetitive reminders" to smoke are perceived as nice and wished, and just like cigarettes, are additionally rewarding. In 2015, the researchers confirmed that in comparison with when ladies are within the luteal section of their menstrual cycle, which is the time frame following ovulation and previous to menstruation, ladies within the follicular section -- which begins at menstruation and continues till ovulation -- have enhanced responses to smoking cues in reward-related mind areas. This discovering led them to additional check whether or not teams differed within the energy of the practical connections that exists between areas exerting cognitive management and reward-related mind areas. The weaker the practical connections between cognitive management mind areas and reward signaling mind areas, the much less potential ladies need to 'Simply Say No' when making an attempt to stop. The ladies within the examine had been separated into two teams -- these of their follicular section and people of their luteal section. Outcomes revealed that in the course of the follicular section, there was diminished practical connectivity between mind areas that helps make good choices (cortical management areas) and the mind areas that comprise the reward middle (ventral striatum), which might place ladies within the follicular section at better threat for continued smoking and relapse. Orienting consideration in direction of smoking cues (photos of smoking reminders reminiscent of a person smoking) was additionally proven to be related weaker connections between cognitive management areas in follicular females. "These information assist current animal information and an rising human literature exhibiting that progesterone might exert protecting results over addictive habits and importantly, the findings present new insights into intercourse variations in smoking habits and relapse," Franklin mentioned. "Apparently, the findings might symbolize a basic impact of menstrual cycle section on mind connectivity and could also be generalizable to different behaviors, reminiscent of responses to different rewarding substances (i.e., alcohol and meals excessive in fats and sugar). "The outcomes from this examine turn into extraordinarily vital as we search for extra methods to assist the over 40 million people within the U.S. alone hooked on cigarettes," Franklin, continued. "After we be taught that one thing so simple as timing a stop date might impression a lady's cessation success, it helps us to supply extra individualized therapy methods for people who're scuffling with dependancy."

"Developing more effective opiate addiction treatments will require a change in the way we view the effects of opiates on the brain. Instead of addiction being a chronic, permanent disease, recent evidence is showing that addiction is controlled by molecular switching mechanisms in the brain, that can be turned on or off with the right interventions" says Dr. Steven Laviolette. Addiction to opiates is spreading and increasing exponentially, and is currently estimated to affect 15.5 million people worldwide. Opiate drugs' addictive properties are largely due to the ability of this class of drugs to produce powerful memories associated with the intense experience of pleasure and euphoria they cause. Environmental reminders triggering the recall of these memories can cause a relapse, and these memories can be considered the primary driver of the addiction cycle, from chronic use, to withdrawal and then memory-triggered relapse. For decades, clinical and pre-clinical rese...